In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis.

@article{Straeter1995InSD,
  title={In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis.},
  author={Joern Straeter and Karin Koretz and Andreas R. G{\"u}nthert and Peter L Moeller},
  journal={Gut},
  year={1995},
  volume={37 6},
  pages={819-25}
}
Physiological regeneration of colonic epithelium entails proliferation at the crypt base and cell loss by shedding or cell death. The aim of this study was to localise and assess the rate of apoptosis in normal and neoplastic colonic epithelium with respect to zones of proliferation. Familial adenomatous polyposis (FAP) was chosen as a model to study neoplastic transformation of colonic mucosa at an early stage. Apoptotic cells were detected in situ by TdT-mediated biotin-dUTP nick end… CONTINUE READING

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