In situ detection of beta-galactosidase in lenses of transgenic mice with a gamma-crystallin/lacZ gene.

@article{Goring1987InSD,
  title={In situ detection of beta-galactosidase in lenses of transgenic mice with a gamma-crystallin/lacZ gene.},
  author={Daphne R Goring and Janet Rossant and Susan Clapoff and Martin L. Breitman and Lap Chee Tsui},
  journal={Science},
  year={1987},
  volume={235 4787},
  pages={456-8}
}
Transgenic mice carrying the gamma 2-crystallin promoter fused to the coding region of the bacterial lacZ gene were generated. The offspring of three founder mice expressed high levels of the enzyme solely in the central nuclear fiber cells of the lens as measured by an in situ assay for the detection of beta-galactosidase activity. These results suggest that gamma 2-crystallin sequences between -759 to +45 contain essential information required for appropriate tissue-specific and temporal… CONTINUE READING

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