In situ detection of Epstein-Barr virus in breast cancer.

  title={In situ detection of Epstein-Barr virus in breast cancer.},
  author={Jan-Show Chu and C C Chen and K J Chang},
  journal={Cancer letters},
  volume={124 1},
Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results… CONTINUE READING


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