In situ depletion of CD4+ T cells in human skin by Zanolimumab

@article{Villadsen2006InSD,
  title={In situ depletion of CD4+ T cells in human skin by Zanolimumab},
  author={Louise S Villadsen and Lone Skov and Tomas Norman Dam and Frederik Dagn{\ae}s-Hansen and Jorgen Rygaard and Janine Schuurman and Paul W H I Parren and Jan G. J. van de Winkel and Ole Baadsgaard},
  journal={Archives of Dermatological Research},
  year={2006},
  volume={298},
  pages={449-455}
}
CD4+ T cells, in activated or malignant form, are involved in a number of diseases including inflammatory skin diseases such as psoriasis, and T cell lymphomas such as the majority of cutaneous T cell lymphomas (CTCL). Targeting CD4 with an antibody that inhibits and/or eliminates disease-driving T cells in situ may therefore be a useful approach in the… CONTINUE READING