In situ cross-linking by cisplatin of nuclear matrix-bound transcription factors to nuclear DNA of human breast cancer cells.

@article{Samuel1998InSC,
  title={In situ cross-linking by cisplatin of nuclear matrix-bound transcription factors to nuclear DNA of human breast cancer cells.},
  author={Shanti K. Samuel and Virginia A. Spencer and Lydia Bajno and J M Sun and Laurel T. Holth and Steffi Oesterreich and James R. Davie},
  journal={Cancer research},
  year={1998},
  volume={58 14},
  pages={3004-8}
}
Cisplatin is an antitumor drug that is used to treat several types of cancers. In this study, we analyzed the proteins that were cross-linked to DNA in situ in MCF-7 human breast cancer cells incubated with cisplatin. We show that cisplatin cross-links nuclear matrix proteins to DNA. In immunoblotting experiments, we found that nuclear matrix-associated transcription factors and cofactors (estrogen receptor, HET/SAF-B, hnRNP K, and histone deacetylase 1) were cross-linked to nuclear DNA. These… CONTINUE READING
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