In situ complement activation by polyethylene wear debris.


A frequent long-term complication of total joint arthroplasty is aseptic loosening, the end result of wear debris accumulation, synovitis, and osteolysis about the implant-bone or cement-bone interface. Complement, an effector system in plasma, synovial fluid, and tissue, has powerful chemotactic, inflammatory, and osteoclast-activating potentials. This… (More)


Cite this paper

@article{Deheer2001InSC, title={In situ complement activation by polyethylene wear debris.}, author={David H Deheer and Joachim Engels and Aaron S Devries and Robert H. Knapp and John Beebe}, journal={Journal of biomedical materials research}, year={2001}, volume={54 1}, pages={12-9} }