In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis.

@article{Mullarky2006InSA,
  title={In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis.},
  author={Isis Kanevsky Mullarky and Frank M. Szaba and C G Winchel and Michelle A. Parent and Lawrence W. Kummer and Nigel Mackman and Lawrence L. Johnson and Stephen T. Smiley},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2006},
  volume={4 7},
  pages={1580-7}
}
BACKGROUND Inflammatory cytokines potently impact hemostatic pathways during infection, but the tissue-specific regulation of coagulation and fibrinolysis complicates studies of the underlying mechanisms. METHODS AND RESULTS Here, we describe assays that quantitatively measuring prothrombinase (PTase), protein C-ase (PCase) and plasminogen activator (PA) activities in situ, thereby facilitating studies of tissue-specific hemostasis. Using these assays, we investigate the mechanisms regulating… CONTINUE READING

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