In situ analysis of cell kinetics in human brain tumors

@article{Morimura1989InSA,
  title={In situ analysis of cell kinetics in human brain tumors},
  author={Tatsuo Morimura and Klaus Kitz and H Budka},
  journal={Acta Neuropathologica},
  year={1989},
  volume={77},
  pages={276-282}
}
A newly developed in vitro labeling method with bromodeoxyuridine (BrdU) identifies S phase cells in situ in freshly obtained surgical tissue of human brain tumors which is subsequently fixed and embedded in paraffin for BrdU immunovisualization. For the first time, the BrdU labeling index (LI) is successfully compared here with the LI obtained by immunostaining of frozen sections of the same tumors with monoclonal antibody Ki-67 which identifies all proliferating cells, i.e., the growth… CONTINUE READING

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