In situ Tip-Recordings Found No Evidence for an Orco-Based Ionotropic Mechanism of Pheromone-Transduction in Manduca sexta

@inproceedings{Nolte2013InST,
  title={In situ Tip-Recordings Found No Evidence for an Orco-Based Ionotropic Mechanism of Pheromone-Transduction in Manduca sexta},
  author={Andreas Nolte and Nico Werner Funk and Latha Mukunda and Petra Gawalek and Achim Werckenthin and Bill S. Hansson and Dieter Wicher and Monika Stengl},
  booktitle={PloS one},
  year={2013}
}
The mechanisms of insect odor transduction are still controversial. Insect odorant receptors (ORs) are 7TM receptors with inverted membrane topology. They colocalize with a conserved coreceptor (Orco) with chaperone and ion channel function. Some studies suggest that insects employ exclusively ionotropic odor transduction via OR-Orco heteromers. Other studies provide evidence for different metabotropic odor transduction cascades, which employ second messenger-gated ion channel families for odor… CONTINUE READING
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