In situ SR function in postinfarction myocytes.

  title={In situ SR function in postinfarction myocytes.},
  author={X Q Zhang and Yon Chiet Ng and Russell Moore and Timothy I Musch and Joseph Y Cheung},
  journal={Journal of applied physiology},
  volume={87 6},
Previous studies have shown lower systolic intracellular Ca(2+) concentrations ([Ca(2+)](i)) and reduced sarcoplasmic reticulum (SR)-releasable Ca(2+) contents in myocytes isolated from rat hearts 3 wk after moderate myocardial infarction (MI). Ca(2+) entry via L-type Ca(2+) channels was normal, but that via reverse Na(+)/Ca(2+) exchange was depressed in 3-wk MI myocytes. To elucidate mechanisms of reduced SR Ca(2+) contents in MI myocytes, we measured SR Ca(2+) uptake and SR Ca(2+) leak in… CONTINUE READING