In silico subtraction approach reveals a close lineage relationship between follicular dendritic cells and BP3(hi) stromal cells isolated from SCID mice.

@article{Wilke2010InSS,
  title={In silico subtraction approach reveals a close lineage relationship between follicular dendritic cells and BP3(hi) stromal cells isolated from SCID mice.},
  author={Gordon Wilke and Gudrun Steinhauser and J Tassilo Gr{\"u}n and Claudia Berek},
  journal={European journal of immunology},
  year={2010},
  volume={40 8},
  pages={2165-73}
}
Organization of the stromal compartments in secondary lymphoid tissue is a prerequisite for an efficient immune reaction. In particular, follicular dendritic cells (FDC) are pivotal for the activation and differentiation of B cells. To investigate the development of FDC, FDC together with tightly associated B cells (FDC networks) were micro-dissected from frozen tissue sections and follicular B cells were sorted by FACS. Using an in silico subtraction approach, gene expression of FDC was… CONTINUE READING