In silico simulations reveal that replicators with limited dispersal evolve towards higher efficiency and fidelity

@article{Szab2002InSS,
  title={In silico simulations reveal that replicators with limited dispersal evolve towards higher efficiency and fidelity},
  author={P{\'e}ter Szab{\'o} and Istv{\'a}n Scheuring and Tam{\'a}s L Cz{\'a}r{\'a}n and E{\"o}rs Szathm{\'a}ry},
  journal={Nature},
  year={2002},
  volume={420},
  pages={340-343}
}
The emergence of functional replicases, acting quickly and with high accuracy, was crucial to the origin of life. Although where the first RNA molecules came from is still unknown, it is nevertheless assumed that catalytic RNA enzymes (ribozymes) with replicase function emerged at some early stage of evolution. The fidelity of copying is especially important because the mutation load limits the length of replicating templates that can be maintained by natural selection. An increase in template… 

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