In silico research in drug discovery.

@article{Terstappen2001InSR,
  title={In silico research in drug discovery.},
  author={Georg C. Terstappen and Angelo Reggiani},
  journal={Trends in pharmacological sciences},
  year={2001},
  volume={22 1},
  pages={
          23-6
        }
}
Target and lead discovery constitute the main components of today's early pharmaceutical research. The aim of target discovery is the identification and validation of suitable drug targets for therapeutic intervention, whereas lead discovery identifies novel chemical molecules that act on those targets. With the near completion of the human genome sequencing, bioinformatics has established itself as an essential tool in target discovery and the in silico analysis of gene expression and gene… CONTINUE READING

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