In silico representation of the liver-connecting function to anatomy, physiology and heterogeneous microenvironments

@article{Yan2004InSR,
  title={In silico representation of the liver-connecting function to anatomy, physiology and heterogeneous microenvironments},
  author={Li Yan and C. Anthony Hunt and G.E.P. Ropella and M. S. Roberts},
  journal={The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
  year={2004},
  volume={1},
  pages={853-856}
}
We have built a collection of flexible, hepatomimetic, in silico components. Some are agent-based. We assemble them into devices that mimic aspects of anatomic structures and the behaviors of hepatic lobules (the primary functional unit of the liver) along with aspects of liver function. We validate against outflow profiles for sucrose administered as a bolus to isolated, perfused rat livers (IPRLs). Acceptable in silico profiles are experimentally indistinguishable from those of the in situ… CONTINUE READING