In silico prediction of yeast deletion phenotypes.

@article{Saha2006InSP,
  title={In silico prediction of yeast deletion phenotypes.},
  author={Soma Saha and Steffen Heber},
  journal={Genetics and molecular research : GMR},
  year={2006},
  volume={5 1},
  pages={224-32}
}
Analysis of gene deletions is a fundamental approach for investigating gene function. We evaluated an algorithm that uses classification techniques to predict the phenotypic effects of gene deletions in yeast. We used a modified simulated annealing algorithm for feature selection and weighting. The selected features with high weights were phylogenetic conservation scores for bacteria, fungi (excluding Ascomycota), Ascomycota (excluding Saccharomyces cerevisiae), plants, and mammals, degree of… CONTINUE READING

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