In silico prediction of the structure of membrane proteins: Is it feasible?

@article{Casadio2003InSP,
  title={In silico prediction of the structure of membrane proteins: Is it feasible?},
  author={Rita Casadio and Piero Fariselli and Pier Luigi Martelli},
  journal={Briefings in bioinformatics},
  year={2003},
  volume={4 4},
  pages={341-8}
}
In the 'omic' era, hundreds of genomes are available for protein sequence analysis, and some 30 per cent of all sequences are of membrane proteins. Unlike globular proteins, a 3D model for membrane proteins can hardly be computed starting from the sequence. Why is this so? What can we really compute and with what reliability? These and other matters are outlined. 

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In silico prediction of the structure of membrane proteins

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