In silico prediction of brain exposure: drug free fraction, unbound brain to plasma concentration ratio and equilibrium half-life.

Abstract

The focus of CNS drug pharmacokinetics programs has recently shifted from determining the total concentrations in brain and blood to considering also unbound fractions and concentrations. Unfortunately, assessing unbound brain exposure experimentally requires demanding in vivo and in vitro studies. We propose a physical model, based on lipid binding and pH… (More)

Topics

Cite this paper

@article{Spreafico2013InSP, title={In silico prediction of brain exposure: drug free fraction, unbound brain to plasma concentration ratio and equilibrium half-life.}, author={Morena Spreafico and Matthew P. Jacobson}, journal={Current topics in medicinal chemistry}, year={2013}, volume={13 7}, pages={813-20} }