In silico preclinical trials: methodology and engineering guide to closed-loop control in type 1 diabetes mellitus.

@article{Patek2009InSP,
  title={In silico preclinical trials: methodology and engineering guide to closed-loop control in type 1 diabetes mellitus.},
  author={Stephen D. Patek and B. Wayne Bequette and Marc Andre Breton and Bruce A. Buckingham and Eyal Dassau and Francis J. Doyle and John Lum and Lalo Magni and Howard C. Zisser},
  journal={Journal of diabetes science and technology},
  year={2009},
  volume={3 2},
  pages={269-82}
}
This article sets forth guidelines for in silico (simulation-based) proof-of-concept testing of artificial pancreas control algorithms. The goal was to design a test procedure that can facilitate regulatory approval [e.g., Food and Drug Administration Investigational Device Exemption] for General Clinical Research Center experiments without preliminary testing on animals. The methodology is designed around a software package, based on a recent meal simulation model of the glucose-insulin system… CONTINUE READING