In silico mutagenesis: a case study of the melanocortin 4 receptor

Abstract

The melanocortin 4 receptor (MC4R) is a G-protein-coupled receptor (GPCR) and a key molecule in the regulation of energy homeostasis. At least 159 substitutions in the coding region of human MC4R (hMC4R) have been described experimentally; over 80 of those occur naturally, and many have been implicated in obesity. However, assessment of the presumably… (More)
DOI: 10.1096/fj.08-127530

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