In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening

Abstract

The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel has been recently proposed as a potential therapeutic target to treat hypertension. In order to gain new insights into the sequence-structure-function… (More)
DOI: 10.1038/s41598-017-07794-5

Topics

8 Figures and Tables

Slides referencing similar topics