In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics.

@article{Ni2017InsilicoIO,
  title={In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics.},
  author={Haibo Ni and Ismail Adeniran and Henggui Zhang},
  journal={Journal of molecular and cellular cardiology},
  year={2017},
  volume={111},
  pages={
          86-95
        }
}
A recent study has identified six novel genetic variations (D322H, E48G, A305T, D469E, Y155C, P488S) in KCNA5 (encoding Kv1.5 which carries the atrial-specific ultra-rapid delayed rectifier current, IKur) in patients with early onset of lone atrial fibrillation. These mutations are distinctive, resulting in either gain-of-function (D322H, E48G, A305T) or loss-of-function (D469E, Y155C, P488S) of IKur channels. Though affecting potassium channels, they may modulate the cellular active force and… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Mechano-electrical feedback underlying arrhythmias: the atrial fibrillation case.

  • Progress in biophysics and molecular biology
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Effects of persistent atrial fibrillation-induced electrical remodeling on atrial electro-mechanics – insights from a 3D model of the human atria

I. Adeniran, D.H.MacIver, +3 authors H. Zhang
  • PLoS One
  • 2015
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Effect of cardiac ventricular mechanical contraction on the characteristics of the ECG : a simulation study

J. C. Hancox I. Adeniran, H. Zhang
  • J . Biomed . Sci . Eng .
  • 2013

Similar Papers

Loading similar papers…