In silico investigation of short QT syndrome-linked potassium channel mutations on electro-mechanical function of human atrial cells

@article{Whittaker2015InSI,
  title={In silico investigation of short QT syndrome-linked potassium channel mutations on electro-mechanical function of human atrial cells},
  author={Dominic G. Whittaker and Michael A. Colman and Haibo Ni and Jules C. Hancox and Henggui Zhang},
  journal={2015 Computing in Cardiology Conference (CinC)},
  year={2015},
  pages={853-856}
}
Short QT syndrome (SQTS) patients are prone to atrial arrhythmias. However, the link between SQTS gene mutations and atrial pro-arrhythmia is not well understood. This study investigated the functional impact of two SQTS-related gain-of-function potassium channel mutations on the electro-mechanical activities of human atrial cells. A contemporary human atrial action potential (AP) model was coupled to the Rice et al. mechanics model. Markov formulations of the rapid and slow delayed rectifier… CONTINUE READING

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