In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells

@article{Naamane2006InSI,
  title={In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells},
  author={Najib Naamane and Jacques van Helden and Decio L. Eizirik},
  journal={BMC Bioinformatics},
  year={2006},
  volume={8},
  pages={55 - 55}
}
Pancreatic beta-cells are the target of an autoimmune attack in type 1 diabetes mellitus (T1DM). This is mediated in part by cytokines, such as interleukin (IL)-1β and interferon (IFN)-γ. These cytokines modify the expression of hundreds of genes, leading to beta-cell dysfunction and death by apoptosis. Several of these cytokine-induced genes are potentially regulated by the IL-1β-activated transcription factor (TF) nuclear factor (NF)-κB, and previous studies by our group have shown that… CONTINUE READING

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Highly Influential
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