In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma

@inproceedings{SanchezDiaz2014InSF,
  title={In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma},
  author={Patricia C. Sanchez-Diaz and Tzu-Hung Hsiao and Yi Zou and Aaron J. Sugalski and Josefine M Heim-Hall and Yidong Chen and A M Langevin and Jaclyn Y. Hung},
  booktitle={Oncoscience},
  year={2014}
}
PURPOSE Osteosarcoma is the most common bone tumor in children, adolescents, and young adults. In contrast to other childhood malignancies, no biomarkers have been consistently identified as predictors of outcome. This study was conducted to assess the microRNAs(miRs) expression signatures in pre-treatment osteosarcoma specimens and correlate with outcome to identify biomarkers for disease relapse. RESULTS A 42-miRs signature whose expression levels were associated with overall and relapse… CONTINUE READING