In silico evaluation, molecular docking and QSAR analysis of quinazoline-based EGFR-T790M inhibitors

@article{AsadollahiBaboli2016InSE,
  title={In silico evaluation, molecular docking and QSAR analysis of quinazoline-based EGFR-T790M inhibitors},
  author={Mohammad Asadollahi-Baboli},
  journal={Molecular Diversity},
  year={2016},
  volume={20},
  pages={729-739}
}
Mutated epidermal growth factor receptor (EGFR-T790M) inhibitors hold promise as new agents against cancer. Molecular docking and QSAR analysis were performed based on a series of fifty-three quinazoline derivatives to elucidate key structural and physicochemical properties affecting inhibitory activity. Molecular docking analysis identified the true… CONTINUE READING