In silico drug discovery: solving the "target-rich and lead-poor" imbalance using the genome-to-drug-lead paradigm.

@article{Pang2007InSD,
  title={In silico drug discovery: solving the "target-rich and lead-poor" imbalance using the genome-to-drug-lead paradigm.},
  author={Yanyang Pang},
  journal={Clinical pharmacology and therapeutics},
  year={2007},
  volume={81 1},
  pages={30-4}
}
  • Yanyang Pang
  • Published 2007 in Clinical pharmacology and therapeutics
Advances in genomics, proteomics, and structural genomics have identified a large number of protein targets. Virtual screening has gained popularity in identifying drug leads by computationally screening large numbers of chemicals against experimentally determined protein targets. In that context, there continues to be a "target-rich and lead-poor" imbalance, reflecting an insufficiency of chemists pursuing drug discovery in academia, the challenge of engaging more chemists in this area of… CONTINUE READING

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