In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.

Abstract

Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently observed in human cancers, making them promising anticancer drug targets. Nonetheless, no effective strategy has been available for the development of Ras inhibitors, partly owing to the absence of well-defined surface pockets suitable for drug binding. Only recently… (More)
DOI: 10.1073/pnas.1217730110

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Cite this paper

@article{Shima2013InSD, title={In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.}, author={Fumi Shima and Yoko Yoshikawa and Min Ye and Mitsugu Araki and Shigeyuki Matsumoto and Jingling Liao and Lizhi Hu and Takeshi Sugimoto and Yuichi Ijiri and Azusa Takeda and Yuko Nishiyama and Chie Sato and Shin Muraoka and Atsuo Tamura and Tsutomu Osoda and Ken-ichiro Tsuda and Tomoya Miyakawa and Hiroaki Fukunishi and Jiro Shimada and Takashi Kumasaka and Masaki Yamamoto and Tohru Kataoka}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2013}, volume={110 20}, pages={8182-7} }