In silico design of clinical trials: A method coming of age

@article{Clermont2004InSD,
  title={In silico design of clinical trials: A method coming of age},
  author={Gilles Clermont and John Bartels and Rukmini Kumar and Gregory M Constantine and Yoram Vodovotz and Carson C. Chow},
  journal={Critical Care Medicine},
  year={2004},
  volume={32},
  pages={2061-2070}
}
Objective:To determine the feasibility and potential usefulness of mathematical models in evaluating immunomodulatory strategies in clinical trials of severe sepsis. Design:Mathematical modeling of immunomodulation in simulated patients. Setting:Computer laboratory. Measurements and Main Results:We introduce and evaluate the concept of conducting a randomized clinical trial in silico based on simulated patients generated from a mechanistic mathematical model of bacterial infection, the acute… 
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