In silico cloning of new endothelial-specific genes

  title={In silico cloning of new endothelial-specific genes},
  author={Lukasz Huminiecki and Roy Bicknell},
  journal={Nature Genetics},
  volume={27 Suppl 1},
The endothelium plays a pivotal role in many physiological and pathological processes and is known to be an exceptionally active transcriptional site. To advance our understanding of endothelial cell biology and to elucidate potential pharmaceutical targets, we developed a new database screening approach to permit identification of novel endothelial-specific genes. The UniGene gene index was screened using high stringency BLAST against a pool of endothelial expressed sequence tags (ESTs) and a… CONTINUE READING