In silico binding characteristics between human histamine H1 receptor and antagonists.

Abstract

It is widely acknowledged that the H(1) receptor antagonists have important therapeutic significance in the treatment of various allergic disorders, but little was known about the binding mode between the receptor and antagonists since the crystal structure of G-protein coupling receptors (GPCRs) were hard to obtain. In this paper, a theoretical three… (More)
DOI: 10.1007/s00894-010-0666-z

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