In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis

@inproceedings{Colman2017InSA,
  title={In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis},
  author={Michael A. Colman and Haibo Ni and Bo Liang and Nicole Schmitt and Henggui Zhang},
  booktitle={PLoS Computational Biology},
  year={2017}
}
A recent experimental study investigating patients with lone atrial fibrillation identified six novel mutations in the KCNA5 gene. The mutants exhibited both gain- and loss-of-function of the atrial specific ultra-rapid delayed rectifier K+ current, IKur. The aim of this study is to elucidate and quantify the functional impact of these KCNA5 mutations on atrial electrical activity. A multi-scale model of the human atria was updated to incorporate detailed experimental data on IKur from both… CONTINUE READING
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