In silico approach to inhibition of tyrosinase by ascorbic acid using molecular docking simulations.

@article{enol2014InSA,
  title={In silico approach to inhibition of tyrosinase by ascorbic acid using molecular docking simulations.},
  author={Fatma Sezer Şenol and Mahmud Tareq Hassan Khan and Gurdal Orhan and Erdem Gurkas and Ilkay Erdogan Orhan and Nese Subutay Oztekin and Fermanis Ak},
  journal={Current topics in medicinal chemistry},
  year={2014},
  volume={14 12},
  pages={
          1469-72
        }
}
Current evidence suggests that endogenous dopamine may act as a neurotoxin following its oxidation to an oquinone and reaction with cellular thiols, which are neutoxic, which may occur spontaneously or via reaction with tyrosinase or some other enzymes. Tyrosinase (E.C. 1.14.18.1) with two cupper ions coordinated by three histidines is a bifunctional enzyme that catalyses both the hydroxylation of tyrosine to L-DOPA and the consequent oxidation of the resulting catechol-containing species to an… CONTINUE READING