In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.

Abstract

Hepatic nuclear factor 4α (HNF4A) is a nuclear transcription factor that regulates the expression of many genes involved in drug disposition. To identify additional molecular mechanisms that regulate HNF4A, we identified microRNAs (miRNAs) that target HNF4A expression. In silico analyses suggested that HNF4A is targeted by many miRNAs. We conducted in vitro… (More)
DOI: 10.1124/dmd.111.040329

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@article{Ramamoorthy2012InSA, title={In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.}, author={Anuradha Ramamoorthy and Lang Li and Andrea Gaedigk and L. DiAnne Bradford and Eric A. Benson and David A. Flockhart and Todd C. Skaar}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2012}, volume={40 4}, pages={726-33} }