In silico and experimental studies of concanavalin A: insights into its antiproliferative activity and apoptotic mechanism.

Abstract

Concanavalin A (ConA), a mannose/glucose-binding legume lectin, has been reported to induce tumor cell death via a mitochondria-mediated autophagic pathway; however, the precise mechanism by which induces cell death remains to be discovered. In this study, we simulated the three-dimensional structure of ConA monomer, its dimer, and tetramer forms and… (More)
DOI: 10.1007/s12010-009-8694-9

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