In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites

@article{Ansari2008InSA,
  title={In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites},
  author={Mohd. Zeeshan Ansari and Jyoti Sharma and Rajesh S. Gokhale and Debasisa Mohanty},
  journal={BMC Bioinformatics},
  year={2008},
  volume={9},
  pages={454 - 454}
}
Secondary metabolites biosynthesized by polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) family of enzymes constitute several classes of therapeutically important natural products like erythromycin, rapamycin, cyclosporine etc. In view of their relevance for natural product based drug discovery, identification of novel secondary metabolite natural products by genome mining has been an area of active research. A number of different tailoring enzymes catalyze a variety of… CONTINUE READING

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