In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Abstract

The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-throughput cell-based screen (1,536-well format) based on proliferation of Plasmodium falciparum (Pf) in erythrocytes. From a screen of approximately 1.7… (More)
DOI: 10.1073/pnas.0802982105

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