In silico Evidence for Binding of Pentacyclic Triterpenoids to Keap1-Nrf2 Protein-Protein Binding Site.

@article{Kamble2017InSE,
  title={In silico Evidence for Binding of Pentacyclic Triterpenoids to Keap1-Nrf2 Protein-Protein Binding Site.},
  author={Sarika M. Kamble and Harun Patel and Sameer N. Goyal and Malleshappa N. Noolvi and Umesh B. Mahajan and Shreesh Kumar Ojha and Chandragouda Raosaheb Patil},
  journal={Combinatorial chemistry & high throughput screening},
  year={2017},
  volume={20 3},
  pages={
          215-234
        }
}
AIM AND OBJECTIVE Kelch like ECH-associated protein 1 (Keap1) and Nuclear factor-E2 related factor 2 (Nrf2) binding is a key step in the ubiquitination and degradation of Nrf2. The compounds inhibiting this binding exert antioxidant actions. Naturally occurring pentacyclic triterpenoids (PTs) and their synthetic derivatives are projected as activators of Nrf2 signalling. The 16-mer Nrf2 peptide binding site on Keap-1 (PDB: 2 FLU) is proposed to be the prospective target where pentacyclic… CONTINUE READING