In silico Analysis of HIV-1 Env-gp120 Reveals Structural Bases for Viral Adaptation in Growth-Restrictive Cells

@article{Yokoyama2016InSA,
  title={In silico Analysis of HIV-1 Env-gp120 Reveals Structural Bases for Viral Adaptation in Growth-Restrictive Cells},
  author={Masaru Yokoyama and Masako Nomaguchi and Naoya Doi and Tadahito Kanda and Akio Adachi and Hironori Sato},
  journal={Frontiers in microbiology},
  year={2016},
  volume={7},
  pages={110}
}
Variable V1/V2 and V3 loops on human immunodeficiency virus type 1 (HIV-1) envelope-gp120 core play key roles in modulating viral competence to recognize two infection receptors, CD4 and chemokine-receptors. However, molecular bases for the modulation largely remain unclear. To address these issues, we constructed structural models for a full-length gp120 in CD4-free and -bound states. The models showed topologies of gp120 surface loop that agree with those in reported structural data… CONTINUE READING
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