In search of rat stem Leydig cells: identification, isolation, and lineage-specific development.

@article{Ge2006InSO,
  title={In search of rat stem Leydig cells: identification, isolation, and lineage-specific development.},
  author={Ren-Shan Ge and Qiang Dong and Chantal M Sottas and Vassilios Papadopoulos and Barry R. Zirkin and Matthew Philip Hardy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 8},
  pages={2719-24}
}
Leydig cells (LCs) are thought to differentiate from spindle-shaped precursor cells that exhibit some aspects of differentiated function, including 3beta-hydroxysteroid dehydrogenase (3betaHSD) activity. The precursor cells ultimately derive from undifferentiated stem LCs (SLCs), which are postulated to be present in testes before the onset of precursor cell differentiation. We searched for cells in the neonatal rat testis with the abilities to: (i) proliferate and expand indefinitely in vitro… CONTINUE READING
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