In search of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors.

  title={In search of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors.},
  author={Rohit Sharma and Yogendra S. Padwad},

Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities

To fully understand and comprehend the anti-aging characteristics of probiotic bacteria; it is imperative that probiotics or their synbiotic amalgamation with plant polyphenols, be studied under the purview of cellular senescence, that may ultimately help devise probiotic-based anti-senescence strategies.

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

Results indicate vital role of adipose tissue-mediated extrinsic factors in shaping macrophage phenotype and functions during aging and indicate that EGCG is a promising candidate in developing preventive therapies aimed at alleviating macrophages inflamm-aging and senescence that may help curb incidences of inflammatory disorders in elderly.

Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

The study of blood factors is a simple and easily accessible way to assess individual health and supplement the traditional indicators of a person's biological age with new objective criteria to prevent or decelerate the development of age-related diseases.

Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct

UVB significantly induced the aging phenotype in keratinocytes and impaired epidermal development and differential expression of the genes regulated senescence was revealed in NHK exposed to UVB.

Are We Ill Because We Age?

As there is no common definition of what aging is, what its causes are, why it occurs, and what should be the target(s) for interventions, it is impossible to conclude that aging is a disease.



Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats.

The authors found a striking reversal in the expression of age-regulated genes in the kidney, many of which linked to inflammation and fibrosis, together with a reduction in the severity of nephropathy lesions in aged rats.

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

The potential mechanisms how mTOR signaling controls lifespan and influences aging-related processes such as cellular senescence, metabolism, and stem cell function are discussed.

Olive polyphenols: new promising agents to combat aging-associated neurodegeneration

The relation between diet components, particularly olive polyphenols, and protection against the occurrence of the most widespread neurodegenerative conditions associated with aging is focused on.

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

This review assesses the use of mTOR inhibitors to treat age-related pathologies, discusses possible molecular mechanisms of action where evidence is available, and considers strategies to minimize undesirable side effects.

New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges

A critical review on aspects related to the use of novel phytochemicals asAnti-aging agents is provided, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives.

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

It is concluded that neither rapa feeding nor CR, in the current form/administration regimen, may be optimal strategies for extending healthy immune function and, with it, lifespan.

TORC1 inhibition enhances immune function and reduces infections in the elderly

It is shown that low-dose TORC1 inhibitor therapy in elderly humans decreased the incidence of all infections, improved influenza vaccination responses, and up-regulated antiviral immunity, as well as an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination in this treatment group.

Polyphenols and aging.

While the mechanisms by which these effects occur are yet to be fully understood, it is evident that further investigation may yield a potential use for polyphenols as pharmacological interventions against specific age-associated diseases.