In search of mediators of skin vasodilation induced by transcutaneous nerve stimulation: III. Increase in plasma VIP in normal subjects and in Raynaud's disease.

@article{Kaada1984InSO,
  title={In search of mediators of skin vasodilation induced by transcutaneous nerve stimulation: III. Increase in plasma VIP in normal subjects and in Raynaud's disease.},
  author={Birger B. Kaada and Eric George Olsen and O V Eielsen},
  journal={General pharmacology},
  year={1984},
  volume={15 2},
  pages={107-13}
}
Previous studies have shown that the widespread and sustained cutaneous vasodilation which can be induced by low-frequency transcutaneous nerve stimulation (TNS) in humans is dependent on a central serotonergic pathway leading to peripheral sympatho-inhibition. In addition, in a bioassay study, the release of a peripheral vasodilator was suggested. However, the TNS-induced dilator response was not blocked by antagonists to a series of known endogenous vasodilators. In the present study another… CONTINUE READING
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