In search of a new paradigm for protective immunity to TB

  title={In search of a new paradigm for protective immunity to TB},
  author={Cl{\'a}udio Nunes-Alves and Matthew G Booty and Stephen M Carpenter and Pushpa Jayaraman and Alissa C. Rothchild and Samuel M Behar},
  journal={Nature Reviews Microbiology},
Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and results are starting to come in. Some of these results are not so encouraging, as exemplified by the latest Aeras-422 and MVA85A trials. Other than empirically determining whether a vaccine reduces the number of cases of active tuberculosis, which is a daunting prospect given the chronic nature of the disease, we have no way of assessing vaccine efficacy. Therefore, investigators seek to identify biomarkers… CONTINUE READING

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