In pursuit of the first recognized epigenetic signal--DNA methylation: a 1976 to 2008 synopsis.

@article{Doerfler2008InPO,
  title={In pursuit of the first recognized epigenetic signal--DNA methylation: a 1976 to 2008 synopsis.},
  author={Walter Doerfler},
  journal={Epigenetics},
  year={2008},
  volume={3 3},
  pages={125-33}
}
A synopsis will be presented of work on DNA methylation, the first epigenetic signal to be recognized. In the author's laboratory, the following problems dealing with DNA methylation have been addressed over the past 32 years: (1) The de novo methylation of foreign DNA integrated into mammalian genomes. (2) Inverse correlations between promoter methylation and activity. (3) The long-term inactivating effect of site-specific promoter methylation. (4) Adenovirus E1 functions in trans and a strong… CONTINUE READING

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