In patients with pseudoxanthoma elasticum a thicker and more elastic carotid artery is associated with elastin fragmentation and proteoglycans accumulation.

@article{Kornet2004InPW,
  title={In patients with pseudoxanthoma elasticum a thicker and more elastic carotid artery is associated with elastin fragmentation and proteoglycans accumulation.},
  author={Lilian Kornet and Arthur A. B. Bergen and Arnold P. G. Hoeks and Jacques P M Cleutjens and R. J. Oostra and Mat J. A. P. Daemen and Simone S van Soest and Robert S. Reneman},
  journal={Ultrasound in medicine & biology},
  year={2004},
  volume={30 8},
  pages={1041-8}
}
Skin biopsies in patients with pseudoxanthoma elasticum (PXE) show elastic fiber fragmentation and calcium and proteoglycans accumulation. Assuming such changes to be present in the artery wall as well, we studied the influence of such alterations on function and structure of the human common carotid artery (CCA). Indeed, elastin fragmentation and increased calcium and proteoglycans content were present in the arteries of the two PXE patients examined. Internal diameter, distension and intima… CONTINUE READING