In ovo carcinogenicity assay (IOCA): evaluation of mannitol, caprolactam and nitrosoproline

@article{Brunnemann2002InOC,
  title={In ovo carcinogenicity assay (IOCA): evaluation of mannitol, caprolactam and nitrosoproline},
  author={Klaus D. Brunnemann and Harald G. Enzmann and Carmen E. Perrone and Michael J. Iatropoulos and Gary M Williams},
  journal={Archives of Toxicology},
  year={2002},
  volume={76},
  pages={606-612}
}
The in ovo carcinogenicity assay (IOCA) was used to examine whether the noncarcinogens ε-caprolactam (CAP), D-mannitol (MAN) and nitrosoproline (NPRO) induce toxicity and subsequently morphological changes in embryonic turkey livers compared with the carcinogen diethylnitrosamine (DEN). Various doses of the test compounds were injected into fertilized turkey or quail eggs prior to incubation. Embryonic livers were collected 3–4 days before hatching and processed for histology. The positive… CONTINUE READING

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