In ovo DNA immunisation followed by a recombinant fowlpox boost is fully protective to challenge with virulent IBDV.

@article{Haygreen2006InOD,
  title={In ovo DNA immunisation followed by a recombinant fowlpox boost is fully protective to challenge with virulent IBDV.},
  author={Elisabeth A Haygreen and Pete Kaiser and Shane C. Burgess and T. Fred Davison},
  journal={Vaccine},
  year={2006},
  volume={24 23},
  pages={4951-61}
}
The aim of this study was to investigate the potential use of DNA vaccination delivered in ovo for protecting against challenge with infectious bursal disease virus (IBDV). Using a plasmid expressing the beta-galactosidase gene, DNA was successfully delivered to the embryo after in ovo injection and localises to the proventriculus and thymus. The coding sequence for the immunogenic IBDV protein, VP2, was cloned into pCI-neo, creating pCI-Vp2. Complete protection against IBDV was obtained by… CONTINUE READING

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