In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality.

@article{Yeap2014InOM,
  title={In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality.},
  author={Bu B. Yeap and Helman Alfonso and Stephen Anthony Paul Chubb and David J Handelsman and Graeme J. Hankey and Osvaldo P. Almeida and Jonathan Golledge and Paul E. Norman and Leon Flicker},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 1},
  pages={E9-18}
}
CONTEXT Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined. OBJECTIVE We assessed associations of T, DHT, and E2 with all-cause and ischemic heart disease (IHD) mortality in older men. PARTICIPANTS Participants were community-dwelling men aged 70 to 89 years who were residing in Perth, Western Australia… CONTINUE READING

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Androgen physiology, pharmacology and abuse

  • DJ Handelsman
  • Endocrinology. 6th ed. Philadelphia,
  • 2010
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