In neuroblastic tumours, Schwann cells do not harbour the genetic alterations of neuroblasts but may nevertheless share the same clonal origin

@article{Bourdeaut2008InNT,
  title={In neuroblastic tumours, Schwann cells do not harbour the genetic alterations of neuroblasts but may nevertheless share the same clonal origin},
  author={Franck Bourdeaut and Agn{\`e}s Ribeiro and Ronald A. Paris and Ga{\"e}lle Pierron and J{\'e}r{\^o}me Couturier and Michel Peuchmaur and Olivier Delattre},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={3066-3071}
}
Neuroblastic tumours are composed of variable proportions of neuroblasts and Schwann cells. Whether both components share a common neoplastic origin is highly debated and discrepant results have been reported about the presence of tumour-related genetic alterations in Schwann cells. We have used X-methylation analysis and array-CGH to investigate contiguous… CONTINUE READING