In multiple myeloma increased thrombopoietin (Tpo) production may be involved in the maintenance of platelet production.

@article{Folman2001InMM,
  title={In multiple myeloma increased thrombopoietin (Tpo) production may be involved in the maintenance of platelet production.},
  author={Claudia C. Folman and Caroline M A de Jong and Masja de Haas and Albert E G K R von dem Borne},
  journal={European journal of haematology},
  year={2001},
  volume={66 5},
  pages={337-41}
}
In multiple myeloma (MM), suppression of haematopoiesis occurs as a result of expansion of malignant cells in the bone marrow. Thrombopoietin (Tpo) levels in patients with impaired platelet production are generally found to be highly elevated. To examine the circulating Tpo levels in patients with MM, Tpo levels were measured in 50 serum samples from 34 patients. Tpo levels were subsequently related to disease stage, and cell numbers and markers, i.e. platelet count, leukocyte count and… CONTINUE READING