In-matrix derivatization and automated headspace solid-phase microextraction for GC-MS determination of amphetamine-related drugs in human hair

@article{Yahata2006InmatrixDA,
  title={In-matrix derivatization and automated headspace solid-phase microextraction for GC-MS determination of amphetamine-related drugs in human hair},
  author={Midori Yahata and Akira Namera and Manami Nishida and Mikio Yashiki and Takako Kuramoto and Kojiro Kimura},
  journal={Forensic Toxicology},
  year={2006},
  volume={24},
  pages={51-57}
}
A fully automated method for analysis of amphetamine-related drugs in human hair by gas chromatography-mass spectrometry (GC-MS) was developed using headspace solid-phase microextraction (SPME) and in-matrix derivatization. Amphetamines were extracted from hair under alkaline conditions, and were simultaneously derivatized to N-ethoxycarbonyl amphetamines with ethylchloroformate in a vial. An SPME fiber was then exposed to the headspace at 80°C for 10 min for extraction. The derivatives… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Clarke’s analysis of drugs and poisons

  • AC Moffat, MD Osselton, B Widdop
  • 3rd edn. Pharmaceutical,
  • 2004
1 Excerpt

Simultaneous detection of some drugs of abuse in saliva samples by SPME technique

  • N Fucci, N De Giovanni, M Chiarotti
  • Forensic Sci Int
  • 2003
1 Excerpt

Automated analysis of methamphetamine and amphetamine in urine using headspace-solid phase microextraction

  • M Yahata, T Kuramoto, A Namera, M Nishida, M Yashiki, T Kojima
  • Jpn J Forensic Toxicol
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…